Cystic Fibrosis Mechanism and Treatment | HHMI BioInteractive Video Video

Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

This animation can be used to illustrate the connection between genotype and phenotype using a human disease example. It also demonstrates how knowledge about the genetic mutations responsible for a particular disease can be used to develop a treatment.

Cystic fibrosis is an autosomal recessive disease caused by any one of more than 2,000 mutations in a gene that codes for the cystic fibrosis transmembrane conductance regulator (CFTR). This protein functions as a channel that transports chloride ions across the membranes of cells that line airways, glands, and the digestive tract. This animation shows how some CFTR mutations prevent the channel from functioning properly, leading to the production of a thick mucus that can obstruct airways and provide a breeding ground for infections. The animation also illustrates the process by which scientists identified small molecule drugs that can improve CFTR channel function and treat the disease in some patients.

About the Site 🌐

This site provides links to random videos hosted at YouTube, with the emphasis on random. 🎥

Origins of the Idea 🌱

The original idea for this site stemmed from the need to benchmark the popularity of a video against the general population of YouTube videos. 🧠

Challenges Faced 🤔

Obtaining a large sample of videos was crucial for accurate ranking, but YouTube lacks a direct method to gather random video IDs.

Even searching for random strings on YouTube doesn't yield truly random results, complicating the process further. 🔍

Creating Truly Random Links 🛠️

The YouTube API offers additional functions enabling the discovery of more random videos. Through inventive techniques and a touch of space-time manipulation, we've achieved a process yielding nearly 100% random links to YouTube videos.

About YouTube 📺

YouTube, an American video-sharing website based in San Bruno, California, offers a diverse range of user-generated and corporate media content. 🌟

Content and Users 🎵

Users can upload, view, rate, share, and comment on videos, with content spanning video clips, music videos, live streams, and more.

While most content is uploaded by individuals, media corporations like CBS and the BBC also contribute. Unregistered users can watch videos, while registered users enjoy additional privileges such as uploading unlimited videos and adding comments.

Monetization and Impact 🤑

YouTube and creators earn revenue through Google AdSense, with most videos free to view. Premium channels and subscription services like YouTube Music and YouTube Premium offer ad-free streaming.

As of February 2017, over 400 hours of content were uploaded to YouTube every minute, with the site ranking as the second-most popular globally. By May 2019, this figure exceeded 500 hours per minute. 📈

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