Professor Roger Seheult, MD discusses the Pfizer / Biontech COVID-19 mRNA vaccine: How it works and what we know about the safety and efficacy at this time.
No mRNA vaccine has ever been approved by the FDA, but Pfizer and BioNTech hope to receive emergency approval based on preliminary data from their ongoing vaccine trial.
This two-dose vaccine regimen has limitations including the need for -70 C refrigeration and many questions remain:
Will the vaccine prevent transmission and asymptomatic spread?
How long will immunity last?
Will “90% effective” hold up to peer-review and additional data when it is gathered?
(This video was recorded on November 12, 2020).
Dr. Seheult is the co-founder and lead instructor at
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LINKS / REFERENCES:
Johns Hopkins Tracker |
https://coronavirus.jhu.edu/map.htmlWorldometer |
https://www.worldometers.info/coronavirus/COVID-19 vaccine tracker (RAPS) |
https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-trackerSafety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates (NEJM) |
https://www.nejm.org/doi/full/10.1056/NEJMoa2027906A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates (bioRxiv) |
https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1.full.pdfPfizer and BioNTech Announce Vaccine Candidate Against COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study (BioNTech) |
https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-announce-vaccine-candidate-against-covid-19Why mRNA represents a disruptive new drug class {BioNTech) |
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MEDIA CONTACT:
Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine
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